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  • Dongmei Ren
  • Dongmei Ren, Ph.D, Professor




    School of Pharmaceutical Sciences
    Shandong University
    No.44, Wenhuaxi Road, Jinan, 250012
    Tel: 0086-531-88382012



    1988--1992: Shandong Medical University , Bachelor

    1992--1995: Shandong Traditional Chinese Medicine University , Master

    2003--2007: Shandong University, Ph. D


    Shandong University, Professor

    2015-2016: Center for Drug Evaluation, China Food and Drug Administration

    2009-2010: University of Arizona, Research associate

    2004-2010: Shandong University, Associate professor

    2005: Center for Drug Evaluation, China Food and Drug Administration

    1997-2004: Shandong University, Lecturer

    1995-1997: Shandong Medical University, Teaching assistant

    1. Isolation and identification of bioactive natural compounds targeting Nrf2-Keap1 pathway

    2. Bioactivity evaluation of Nrf2 activators for cancer chemoprevention

    3. Develpoment of novel traditional chinese medicine originated from herbs 



    1. Investigation of quassinoids targeting Nrf2 from Brucea javanica, National Natural Science Foundation, No81173528,580000, PI.

    2. Flavonoidal alkaloids from Dracocephalum rupestre, National Natural Science Foundation, No. 30672611, 280000, PI.

    3. Nrf2 activators from Dracocephalum plants, National Natural Science Foundation No. 30973622, 320000, PI.

    4. Total flavonoids from Dracocephalum moldavicaShandong Key Technologies R & D Program, No. 2006GG2202058PI,¥100000

    5. Flavonoidal alkaloids from Dracocephalum plants, Foundation for Excellent Young Scientists in Shandong ProvinceNo. 2008BS02015PI,¥60000

    7. Flavonoidal alkaloids from Dracocephalum plantsChina Postdoctoral Science FoundationNo. 20080441137PI, 30000  6. Phytochemicals targeting ARE-Nrf2-Keep1 pathwayIndependent Innovation Foundation of Shandong University, No. 2012TS203, 100000, PI,


    1. Zhao LJ#, Wen Q#, Yang GT, Huang ZQ, Shen T, Li HZ, Ren DM*. (2016) Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway. Phytomedicine. 23(2): 114-122.

    2. Li HZ, Hou Z, Li C, Zhang Y, Shen T, Hu QW, Ren DM *. (2015) Three pairs of diastereoisomeric flavanone glycosides from Viscum articulatum. Fitoterapia. 102:156-162.

    3. Yang S, Shen T, Zhao LJ, Li C, Zhang Y, Lou HX, Ren DM*. (2014) Chemical constituents of Lobelia chinensis. Fitoterapia. 93, 168-174.

    4. Shen T, Chen XM, Harder B, Long M, Wang XN, Lou HX, Wondark G, Ren DM*, Zhang D*. (2014) Plant extracts of the family Lauraceae: A potential resource for chemopreventive agents that activate the Nrf2/ARE pathway. Planta Med. 80 (5), 426-434

    5. Yang S, Li C, Wang SQ, Zhao LJ, Hou Z, Lou HX, Ren DM*. (2013) Chiral separation of two diastereomeric pairs of enantiomers of novel alkaloid-lignan hybrids from Lobelia chinensis and determination of the tentative absolute configuration. J Chromatogr A. 1311, 134-139.

    6. Yang S, Wang LM, Guo XJ, Lou HX and Ren DM*. (2013) A new flavonoid glycoside and other constituents from Dracocephalum moldavica. Nat. Prod. Res. 27(3), 201-207

    7. Jing X§, Ren DM§ (co-first author), Wei XB, Shi HY, Zhang XM, Perez R.G., Lou HY*,

    Lou HX. (2013) Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. Toxicol. Appl. Pharmacol. 273(3), 672-679.

    8. Wang LM, Wang SQ, Yang S, Guo XJ, Lou HX and Ren DM*. (2012) Phenolic alkaloids from the aerial parts of Dracocephalum heterophyllum. Phytochemistry. 82, 166-171.

    9. Hu QW, Zhang DD, Wang LM, Lou HX and Ren DM*. (2012) Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Food Chem. Toxicol. 50, 1927-1932.

    10. Ren DM, Villeneuve NF, Jiang T, Wu TD, Lau A, Toppin AH and Zhang DD*. (2011) Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A 108 (4), 1433 – 8. 


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